PREPARATION AND CHARACTERIZATION OF A NOVEL STARCH-BASED INTERPOLYELECTROLYTE COMPLEX AS MATRIX FOR CONTROLLED DRUG RELEASE

H. PRADO; M. C. MATULEWICZ; P. BONELLI; A. L. CUKIERMAN

CARBOHYDRATE RESEARCH

Elsevier B.V.

Lugar: Amsterdam, Holanda; Año: 2009 vol. 334 p. 1325 - 1331

0008-6215

A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenanas the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range.