INVESTIGADORES
CASTRO Gerardo Daniel
artículos
Título:
Dimethyldisulfide formation during trichloromethyl radical attack on methionine
Autor/es:
G.D. CASTRO; M.I. DÍAZ GÓMEZ; J.A. CASTRO
Revista:
BIOCHEMICAL PHARMACOLOGY
Editorial:
Elsevier
Referencias:
Año: 1989 vol. 38 p. 4145 - 4147
ISSN:
0006-2952
Resumen:
Carbon tetrachloride hepatotoxicity has been considered to be related to trichloromethyl free radical formation and its interaction to give protein and/or lipid adducts, and/or to the initiation of a lipid peroxidation process of polyunsaturated fatty acids from cellular membranes that might occur directly or more likely after formation of Cl3CO2 (trichloromethylperoxyl) radical. In the course of previous studies from our laboratory, we reported that chemically produced CCl3 (trichloromethyl radical) was able to interact with several amino acids to give adducts and with methionine to lead to the formation of volatile products of garlic-like odor. In this work we analyzed the structure of these volatile products formed when chemically produced CCl3 interacts with methionine and whether enzymatically produced CCl3 may be able to lead to a similar end product.
