INVESTIGADORES
CASTRO Gerardo Daniel
artículos
Título:
DNA bases attack by reactive metabolites produced during carbon tetrachloride biotransformation and promotion of liver microsomal lipid peroxidation
Autor/es:
G.D. CASTRO; M.I. DÍAZ GÓMEZ; J.A. CASTRO
Revista:
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
Editorial:
PJD Publications
Referencias:
Lugar: Westbury, NY, EE.UU.; Año: 1997 vol. 95 p. 253 - 258
ISSN:
1078-0297
Resumen:
Free radicals produced during carbon tetrachloride biotransformation and the promoted lipid peroxidation process of liver microsomal lipids are able to attack the DNA bases guanine, cytosine and thymine to give at least three altered bases. They were identified as 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua); 5-hydroxycytosine (5OHCyt) and 5-hydroxymethyluracil (5OHMeU). No adenine adducts were detected. If these altered bases were formed during carbon tetrachloride poisoning and were not adequately repaired before cell replication, serious permanent consequences for liver cell DNA could be expected and this might be somehow involved in the liver carcinogenic effects of the haloalkane.
