RELEVANCE OF POLYPEPTIDE GALNAC-TRANSFERASE 3 IN THE HUMAN HEALTH

IRAZOQUI FJ; GARAY, YC; PARODI P; FERRERO, FA; ANGELONI G

Mar del Plata

Congreso; LXVII Reunion Anual de la Sociedad Argentina de Investigación Clínica; 2022

Sociedad Argentina de Investigación Clínica

Polypeptide GalNAc-transferase 3 (ppGalNAc-T3) is an enzyme involved in the initiation of O-GalNAc glycan biosynthesis. Acting as a writer of frequent post-translational modification (PTM) on human proteins, ppGalNAc-T3 has key functions in the homeostasis of human cells and tissues. This molecule has relevant roles in the biosynthesis of O-GalNAc glycans, as well as in biological functions related to human physiological and pathological conditions. With main emphasis in ppGalNAc-T3, we draw attention to the different ways involved in the modulation of ppGalNAc-Ts enzymatic activity. In addition, different subcellular localizations of ppGalNAc-T3 are represented, highlighting critical intrinsic and extrinsic functions in cellular physiology that are exerted by ppGalNAc-T3-synthesized PTMs. Moreover, we update on several human pathologies associated with dysfunctional ppGalNAc-T3. Finally, biotechnological tools as new therapeutic options for the treatment of pathologies related to altered ppGalNAc-T3 are considered.