INVESTIGADORES
GARCIA VESCOVI Eleonora
congresos y reuniones científicas
Título:
Structural basis for long chain unsaturated fatty acids as signals of the Salmonella PhoP/PhoQ virulence system
Autor/es:
CARABAJAL, MA; RASIA, RM; GARCÍA VÉSCOVI, E.
Lugar:
Ciudad Autónoma de Buenos Aires
Reunión:
Congreso; LIII Reunión de la Sociedad Argentina de Investigación Bioquímica y Biología Molecular (SAIB); 2017
Institución organizadora:
SAIB
Resumen:
Salmonella is an enteropathogen that causes a wide range of diseases in humans and animals. In S. typhimurium, the PhoP/PhoQ two-component system (TCS), composed by PhoQ, the histidine kinase sensor, and PhoP the cognate transcriptional regulator, controls key virulence phenotypes such as the invasion and proliferation within host cells. As signal transduction in mammals does not involve TCS, the inhibition of histidine kinases is an attractive target to develop new antimicrobial agents. By using a bio-guided strategy, we have previously discovered that long chain unsaturated fatty acids (LCUFAs) repress the transcription of PhoP‑regulated genes by inhibiting the PhoQ autokinase activity. The aim of this work is to analyze the specificity of the inhibition and the molecular basis for this action.
