Regulation of magnesium homeostasis in Salmonella: Mg2+ targets the mgtA transcript for degradation by RNase E

SPINELLI, S. V.; PONTEL, L.. B.; GARCÍA VÉSCOVI, E.; SONCINI, F. C.

FEMS MICROBIOLOGY LETTERS

Blackwell Pub

Lugar: England; Año: 2008 vol. 280 p. 226 - 234

0378-1097

Extracellular Mg21 controls the activation of the Salmonella PhoP/PhoQ regulatory system. One of the adaptive responses driven by PhoP/PhoQ includes the transcriptional induction of mgtA and mgtCB, which encode two P-type Mg+2 21 controls the activation of the Salmonella PhoP/PhoQ regulatory system. One of the adaptive responses driven by PhoP/PhoQ includes the transcriptional induction of mgtA and mgtCB, which encode two P-type Mg+2mgtA and mgtCB, which encode two P-type Mg+2 transporters. Mg+2 also controls mgtA expression by a riboswitch located in its 50-untranslated region (5´UTR). In this work, it was shown that the 5´UTR of both also controls mgtA expression by a riboswitch located in its 50-untranslated region (5´UTR). In this work, it was shown that the 5´UTR of both0-untranslated region (5´UTR). In this work, it was shown that the 5´UTR of both mgtA and mgtCB is responsible for a fine-tuned Mg2+-dependent regulation of these genes. Evidence was also provided that the Mg2+ riboswitch targets the mgtA and mgtCB is responsible for a fine-tuned Mg2+-dependent regulation of these genes. Evidence was also provided that the Mg2+ riboswitch targets the mgtA riboswitch targets the mgtA transcript for degradation by RNase E when cells are grown in high Mg2+ environments.