CAROTID PATHOLOGY: EXTRA-CARDIAC END-ORGAN DAMAGE IN ELDERLY HYPERTENSIVES?

OTERO-LOSADA M.; SANCHEZ GELOS D.; GOMEZ-LLAMBI H.; AZZATO F.; AMBROSIO G.; MILEI J.

Milán

Congreso; 25th European Meeting on Hypertension and Cardiovascular Protection; 2015

European Society of Hypertension. International Society of Hypertension

Otero-Losada M1, Sánchez Gelós D1, Gómez Llambí H1, Azzato F1, Ambrosio G2, Milei J1Objective.This study examines carotid artery lesions as a sign of preclinical TOD in relation with cardiac remodeling in elderly hypertensives. Design and methodConsecutive outpatients (32 men, 91 women, over 65 y.o.) were clinically and neurologically evaluated: 51 were normotensive controls and 72 were treated hypertensives. Patients continued with their antihypertensive treatments. Laboratory and electrocardiographic evaluations were performed. Blood pressure was measured 5-min after resting in the sitting position. Twenty four-hour ambulatory blood pressure monitoring (ABPM) was performed recording data every 15 min/ day time and every 20 min/ at night. Morning surge (MS) was calculated as the difference between mean systolic blood pressure (SBP) within 2 hours after awakening and mean SBP within the hour of the lowest sleep SBP.Ambulatory blood pressure variability (BPVar) was estimated as the SD of the 24-hr mean blood pressure recording. Carotid artery evaluation was performed in the dorsal decubitus. ResultsAll treated hypertensive patients had normal office BP at the study time. Carotid pathology was found in 22% of controls and 71% of hypertensives. Prevalence of LVH was 33% in controls and 67% in hypertensives.Increased SBPVar was observed in 51/72 hypertensives (71%) and in 11/51 controls (22%). Carotid injury and increased 24-hr SBPVar were correlated (p