INVESTIGADORES
OTERO-LOSADA Matilde Estela
artículos
Título:
Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection,
Autor/es:
OTERO-LOSADA M.; GOMEZ-LLAMBI H.; OTTAVIANO G; CAO G.; MULLER A; AZZATO F.; AMBROSIO G.; MILEI J
Revista:
MEDIATORS OF INFLAMMATION
Editorial:
HINDAWI PUBLISHING CORPORATION
Referencias:
Lugar: New York; Año: 2016 vol. 2016 p. 1 - 11
ISSN:
0962-9351
Resumen:
The pathophysiology of renal complications associated with metabolic syndrome (MetS) is not clear, partly due to few studies presenting histopathological data. Here we report experimental evidence confirming renal histopathology in relation with proinflammatory mediators and oxidative metabolism in MetS induced by cola drinking in rats.Male Wistar rats drank ad libitum regular cola (C, n=12) or tap water (W, n=12). Measures/recordings: body weight (weekly), nutritional data (twice a week); plasma glucose, cholesterol fractions, TG, urea and creatinine (enzymocolorimetry), coenzyme Q-10 (RP-HPLC-ED), SBP (plethysmography) and echocardiograms (awake rats) at 0 mo and 6 mo. Atherogenic index in plasma (AIP) was calculated. At 6 months euthanasia was performed. Kidneys were excised and processed for histopathology and immunohistochemistry (IL-6 and TNFα). Glomerulosclerosis and histopathology score were semiquantitatively determined. Compared with W, C rats showed: I). overweight (+8%, p
