INVESTIGADORES
PONCE DAWSON Silvina Martha
congresos y reuniones científicas
Título:
Observing the Dynamics of Luminal and Cytosolic Calcium During IP3R-Mediated Calcium Signals
Autor/es:
LOPEZ, LUCÍA; SIGAUT, LORENA; PONCE DAWSON, SILVINA
Lugar:
San Francisco
Reunión:
Congreso; 58th Annual Meeting Biophysical Society; 2014
Institución organizadora:
Biophysical Society
Resumen:
Ca2+ signaling is ubiquitous across cell types. Ca2+ liberation through inositol 1,4,5-trisphosphate receptors (IP3Rs) is a key component of the Ca2+ signaling toolkit. The role of cytosolic calcium on the kinetics of IP3R´s and on the dynamics of the evoked signals has been studied at large both experimentally and by modeling. The role of luminal calcium has not been investigated with that much detail although it has been found that it is relevant for signal termination in the case of Ca2+ release through Ryanodine Receptors.
