44) Effects of Atenolol injected into the Nucleus Accumbens Septi in Rats in the Elevated Plus Maze.

LLANO LOPEZ, N.H.; MELONARI, P. ; OLGUIN, M. ; FRAILE, M.D.; LANDA, A.I.; GARGIULO, P.A.

Journal of Basic and Clinical Physiology and Pharmacology

De Gruyter

Año: 2020

0792-6855

44) Effects of Atenolol injected into the Nucleus Accumbens Septi in Rats in the Elevated Plus Maze. Llano López, L. H.; Melonari, P.; Olguin, M.; Fraile, M.D.; Landa, A.I.; Gargiulo, P.A. J Basic Clin Physiol Pharmacol. 2020. Jun 29. /j/jbcpp.ahead-of-print/jbcpp-2020-0003/jbcpp-2020-0003.xml.doi: 10.1515/jbcpp-2020-0003. Online ahead of print.Abstract.Background. In previous studies, we have observed that glutamate antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the elevated plus maze (EPM) test in rats. In the present study, the effect of Atenolol, a specific Beta Adreno-receptor antagonist in the EPM was studied in male rats bilaterally cannulated NAS. Methods. Rats were divided into five groups that received either 1 μL injections of saline or atenolol in different doses (0.75, 1 or 2 μg/1 μL, n=15-16) 15 min before testing.Results. Time Spent in the Open Arm was modified by treatment (F=4.563, p=0.006, df 3). This was increased by the lowest dose of atenolol (p