Disinhibitory-like effect induced by injection of chlorazepate dipotassium within the medial prefrontal cortex of male rats in the plus maze test.

LLANO L, CAIF F, FRAILE M, LANDA AI, GARGIULO PA.

San Luis, Argentina.-

Congreso; XXIV Reunión Anual de la Sociedad de Biología de Cuyo. San Luis, 30/11 a 03/12 de 2006. Abstract en prensa en Biocell.; 2006

Sociedad de Biología de Cuyo.-

Disinhibitory-like effect induced by injection of chlorazepate dipotassium within the medial prefrontal cortex of male rats in the plus maze test. LLANO L, Caif F, Fraile M, Landa AI, Gargiulo PA. Lab. Neuroc. Ps. Exp. (IMBECU-CONICET). A. Farm. D. Patol. F.C.M. U.N.C.-      The medial pre-frontal cortex (mPFC), like amygdala (Amy) and ventral hippocampus (Hip), projects to the Nucleus Accumbens Septi (Acc) through glutamatergic pathways. The mPFC projections have been implicated in goal directed behaviors. Glutamatergic transmission within Acc modulates these effects. We studied here behavioral changes induced in the plus maze by the injection of chlorazepate dipotassium within one of the origin nucleus of Acc afferences, mPFC. Rats bilaterally implanted by stereotaxic surgery were injected with saline (1 ìl each side, n=15-18), or chlorazepate dipotassium (1 or 2 ìg in 1 ìl, n=15-18). The drug injection induced a decrease in time per entry (p<0.05 for both doses) when compared to its control group. We conclude that GABAergic blockade within mPFC leads to behavioral stereotyped entries to the open arm when injected within the mPFC. Present study was supported with a grant of the Secretary of Science and Technology of the National University of Cuyo (06/J164).