146) Delayed Effect of Tranylcypromine in the Rat Forced Swimming Test.

MARQUEZ HERRERO, S.; HERNÁNDEZ, JI; MARTÍN CUNIETTI J; IRIBAS, F.; LORENZO, S.; PINTO, G. ; ROMANOWICZ, E.; FARIAS, K.; BEREA, D. ; FRIAS, B.; GUEVARA, M.A.; GARGIULO, P.A.

Merlo. San Luis.

Congreso; XXXV Reunión Científica Anual de la Sociedad de Biología de Cuyo. Merlo, San Luis. 6-7 de Diciembre de 2017.-; 2017

Sociedad de Biología de Cuyo.

146) Marquez Herrero S, Hernandez JI, Martín Cunietti J, Iribas F, Lorenzo S, Pinto G, Romanowicz E, Farias K, Berea D, Frias B, Guevara M, Gargiulo PA. Delayed Effect of Tranylcypromine in the Rat Forced Swimming Test. XXXV Reunión Científica Anual de la Sociedad de Biología de Cuyo. Merlo, San Luis. 6-7 de Diciembre de 2017. A Publicar en Revista Biocell.- Major Depression is a prevalent, serious, recurrent psychiatric disorder that has been ranked by the WHO as the fourth leading cause of disability worldwide. Nowadays, the Mono-amine oxidase Inhibitors are used for treating patients with treatment resistant depression. However, some authors refer to this group as one of the most efficient antidepressants. The aim of this investigation is to establish the doses in which Tranylcypromine has an antidepressant effect to analyze pharmacological interactions in future researches. Holtzman rats were treated with saline solution, Tranylcypromine 2.5 mg/kg (T 2.5), 5 mg/kg (T 5) or 10 mg/kg (T 10) and were tested in the forced swimming test 30 minutes later. T 10 rats showed an increased climbing time when compared to saline, T 5 and T 2.5 (p