Comparison of behavioural patterns displayed by four different strains of rats in the Enriched Hole Board test.

ORCE, I,G, CALDERÓN M, SERRANO L, SORIA G, FRAILE M, LANDA AI, GARGIULO PA.

San Luis, Argentina.-

Congreso; XXIV Reunión Anual de la Sociedad de Biología de Cuyo. San Luis, 30/11 a 03/12 de 2006. Abstract en prensa en Biocell.; 2006

Sociedad de Biologia de Cuyo.

Comparison of behavioural patterns displayed by four different strains of rats in the Enriched Hole Board test. ORCE IG (georginaorce@gmail.com),Calderón M, Serrano L, Soria G, Fraile M, Landa AI, Gargiulo PA. Lab. Neuroc. Ps. Exp. (IMBECU-CONICET). A. Farm. D. Patol. F.C.M. U.N.C.-      Genetic of behaviour studies differences between individual patterns despite environmental conditions. In previous studies we have observed strains differences in Rattus norvegicus. The aim of the present study is to measure behavioural patterns displayed in an enriched hole board test by four different strains of rats (Holtzman [H], Wistar [W], Atriche IPL [A] y Sprague Dawley [SD]). Male rats weighing 230-250 g (n=15) were used. The following parameters were considered: ambulatory movements, non ambulatory movements, number of movements, rearing, horizontal activity, number of fecal boli, sniffing, head dipping, total exploration and time of contact with the novel object. The A strain showed a significant increase of ambulatory movements when compared with H and SD (p<0.05) and W (p<0.01) and number of movements compared to W (p<0.01), and a higher number of fecal boli vs H and W (p<0.001). SD differed also of H (p<0.01) and W (p<0.001) in the number of fecal boli, that were increased. No differences were observed in the hole exploration. We conclude that these genetic differences could be interpreted as a desinhibitory pattern of A strain when compared with other groups. Present study was supported with a grant of the Secretary of Science and Technology of the Nat. University of Cuyo (06/J164).