CONICET | Buscador de Institutos y Recursos Humanos

Working memory and executive functions displayed in different strains of rats in the Hole Board test. ORCE IG (georginaorce@gmail.com),Calderón M, Serrano L, Soria G, Fraile M, Landa AI, Gargiulo PA. Lab. Neuroc. Ps. Exp. (IMBECU-CONICET). A. Farm. D. Patol. F.C.M. U.N.C.- Hole board test is usually accepted as a working memory and executive functions test. In the genetic of behaviour comparisons between individual patterns despite environmental conditions are studied. The aim of the present study is to evaluate working memory and executive functions comparing behavioural patterns displayed by four different strains of Rattus norvegicus (Holtzman [H], Wistar [W], Atriche IPL [A] y Sprague Dawley [SD]). Male rats weighing 230-250 g (n=15) were used. The following parameters were considered: ambulatory movements, non ambulatory movements, number of movements, rearing, horizontal activity, number of fecal boli, sniffing, head dipping and total exploration. The A strain showed a significant increase of ambulatory movements when compared with H (p<0.001), SD (p<0.01) and W (p<0.001), and horizontal activity compared to W (p<0.001), H and SD (p<0.05), and a higher number of fecal boli vs H (p<0.01) and W (p<0.05). A showed also lower values in sniffing, head dipping and total exploration of hole when compared with the other groups. We conclude that these genetic differences could be interpreted as a desinhibitory pattern of A strain when compared with other groups, with prevalence of locomotor activity and a decrease in holes exploration. Present study was supported with a grant of the Secretary of Science and Technology of the Nat. University of Cuyo (06/J164).

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