Behavioural profile induced by injection of chlorazepate dipotassium within the hippocampus of male rats in the plus maze test.

LLANO L, CAIF F, FRAILE M, LANDA AI, GARGIULO PA.

San Luis, Argentina.-

Congreso; XXIV Reunion Anual de la Sociedad de Biologia de Cuyo. San Luis, 30/11 a 03/12 de 2006. Abstract en prensa en Biocell.; 2006

Sociedad de Biologia de Cuyo.-

Behavioural profile induced by injection of chlorazepate dipotassium within the hippocampus of male rats in the plus maze test. LLANO L, Caif F, Fraile M, Landa AI, Gargiulo PA. Lab. Neuroc. Ps. Exp. (IMBECU-CONICET). A. Farm. D. Patol. F.C.M. U.N.C.-      The ventral hippocampus (Hip), like medial pre-frontal cortex (mPFC) and amygdala (Amy), projects to the Nucleus Accumbens Septi (Acc) through glutamatergic pathways. Glutamatergic transmission within Acc modulates the effects of these projections, mainly Hip, that has a gating effect on Acc afferences. We studied here behavioral changes induced in the plus maze by the injection of chlorazepate dipotassium within origin nucleus of Acc afferences, Hip in this case. Rats bilaterally implanted by stereotaxic surgery were injected with saline (1 ìl each side, n=15-18), or chlorazepate dipotassium (1 or 2 ìg in 1 ìl, n=15-18). The drug injection induced an increase in the time spent in the open arm in saline controls, that were decreased by the lower but not the higher dose (p<0.05), like open arm entries (p<0.05). The open/closed arm entries, starting also with high control values, were decreased by both drug doses (p<0.05). We conclude that GABAergic blockade within Hip leads to an interference with hippocampal modulation of anxiety and environment recognition. Present study was supported with a grant of the Secretary of Science and Technology of the National University of Cuyo (06/J164).