30) Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the Nucleus Accumbens Septi.

LLANO LÓPEZ L; CAIF F.; FRAILE M.; TINNIRELLO, B.; LANDA A.; LAFUENTE, J.V.; BAIARDI, G.C.; GARGIULO P.A.

PHARMACOLOGICAL REPORTS

POLISH ACAD SCIENCES INST PHARMACOLOGY

Año: 2013

1734-1140

30) Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the Nucleus Accumbens Septi. Llano López L; Caif F.; Fraile M.; Tinnirello, B.; Landa A.; Lafuente, J.V.; Baiardi, G.C.; Gargiulo P.A. Pharmacological Reports. In Press. 2013. LLANO LÓPEZ L.; CAIF F.; FRAILE M.; TINNIRELLO B.; LANDA A.; LAFUENTE, J.V.; GARGIULO P. A. Differential behavioral profile induced by the injection of Dipotassium Chlorazepate within brain areas that project to the nucleus accumbens septi. Background: The effect of the agonism on γ-Amino-Butiric-Acid (GABA) receptors was studied within medial Prefrontal Cortex (mPFC), Amygdala (AMY) and Ventral Hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. These structures send glutamatergic projections to the Nucleus Accumbens Septi (NAS), in which interaction and integration between these afferent pathways has been described. In a previous study of our group, blockade of glutamatergic transmission within NAS induced an anxiolytic like effect. Methods: Three rat groups received either saline or Dipotassium Chlorazepate (1 or 2 g/1 l solution) 15 min before testing. Time spent in the open arms (TSOA), time per entry (TPE), extreme arrivals (EA), open and closed arms entries (OAE, CAE) and relationship between open- and closed- arms quotient (OCAQ) were recorded. Results: In the AMY Injected group TSOA, OAE and EA were increased by the higher doses of Dipotassium Chlorazepate (p