INVESTIGADORES
BRAVO ALMONACID Fernando Felix
artículos
Título:
Neurospora crassa cDNA clones coding for a new member of the ras protein family
Autor/es:
D.L. ALTSCHULER; A. MURO; A. SCHIJMAN; F. BRAVO ALMONACID; H.N. TORRES
Revista:
FEBS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 1990 vol. 273 p. 103 - 106
ISSN:
0014-5793
Resumen:
A new member of the ras gene family was characterized from Neurospora crassa cDNA libraries. The clone designated N&as codes for a polypeptide containing 213 amino acids (Mr 24000). This polypeptide is 84% homologous to the H-ras-I domain comprising the first 80 amino acids and 60% homologous to the next 84 residues. The NC-ras polypeptide contains all the well-known sequences involved in the interaction with GTP/GDP, the recognition of the Y 13-259 neutralizing antibody, the effector site for interaction with GAP proteins, and the CAAX acylation motif in the COOH-terminal.
