The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia

GAMBERALE R; FERNÁNDEZ CALLOTTI P; SÁNCHEZ AVALOS JC; ALBERTO MF; GEFFNER JR; GIORDANO M

HAEMATOLOGICA

Año: 2006 vol. 91 p. 574 - 576

0390-6078

Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-g, a key cytokine in the pathogenesis of AHA.