Effect of cyclophosphamide on the clearance of IgG-sensitized red cells in mice

PALERMO M; GIORDANO M; ISTURIZ, MA

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY

Elsevier

Año: 1991 vol. 58

0090-1229

The effects of cyclophosphamide (Cy) on the clearance of IgG-sensitized erythrocytes(EA) were examined. The results clearly indicate that Cy treatment enhances the capacityof the mononuclear phagocytic system to remove antibody-coated cells from the circulationin normal and decomplemented mice. The enhanced rate of clearance is theconsequence of an increased uptake of EA by the liver and spleen. We explored thepossibility that the enhancement of Fc receptor-mediated clearance might be an importanteffect to be taken into account in the search for a more effective therapy of immunecomplexes diseases.