INVESTIGADORES
OLIVERI Maria Beatriz
congresos y reuniones científicas
Título:
STUDY OF BONE MASS AND METABOLISM IN GAUCHER DISEASE
Autor/es:
OLIVERI BEATRIZ; PARISI MS; GOLDSTEIN G; OCHOA F
Lugar:
Santiago de Chile
Reunión:
Simposio; Simposio Latinoamericanode Enfermedades de DepĆ³sito Lisosomal; 2004
Resumen:
INTRODUCTION: Gaucher Disease (GD) decreased Acid -Glucosidase or Glucocerebrosidase activity produces accumulation of glucocerebrosides in the reticuloendothelial system. 80% of patients with type l GD have skeletal involvement (bone pains, bone marrow infiltration, osteopenia, pathological fractures, osteonecrosis). CONCLUSIONS: l) A significant reduction of bone mass was observed. 2) The bone remodelling parameters were altered due to an increase in bone resorption. 3) The bone mass alteration was less in patients with an ERT dose :60 UI/kg/day 4) These findings suggest the need of higher ERT doses and the importance of assessing the therapy with anti-resorption drugs as co- adjuvant to improve bone mass.
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