Vitamin D Status/ Insufficiency May Predict Physical Performance in a Group of Osteopenic/ Osteoporotic Women. Preliminary Study

S. MASTAGLIA; M SEIJO; D. MUZIO; B. OLIVERI

Honolulu - Hawaii - USA

Congreso; 29th Anual Meeting ASBMR; 2007

ASBMR

Hypovitaminosis D is frequent in population over 65 years of age, producing a secondaryhyperparathyroidism, increase of bone remodeling, bone loss and osteoporotic fractures,loss of the muscle force function. The aim of this study was to assess the vitamin D(25OHD) nutritional state in osteopenic/osteoporotic women >65 and the relationship withmuscle force and function. To date, forty women were assessed, with an average age(X±DS) 71.2±5.3, body mass index (BMI) 27.5±4.2, with a bone mineral density (BMD) (DXA-LUNAR) of femoral neck (FN) 0.752±0.71 (T- 1.9). The exclusion criteria appliedwere: having received vitamin D during the year preceding the study, pathology ormedication affecting mineral metabolism, neurological and/or motor-function disease. Thephysical performance of lower limbs (walking speed, balance, standing-up and sittingdown)and the hip force with a dynamometer was assessed. The population sample wasdivided into two groups, taking as cut point 20ng/ml of 25OHD (Lips P Endocr Rev 2001):Group 1 (G1): > 20 ng/ml, Group 2: (G2) £ 20 ng/ml. The results obtained are shown inthe following table:n Age(years)BMD(g/cm2)CF25OHD(ng/ml)LeftHip FlexionLeftHipAbductionPhysicalPerformanceG1 20 70.1±3.3 0.748±0.07 31.85±6.4 13.8±1.8 7.33±1.66 11.1G2 20 71.6±5.9 0.755±0.06 12.9±3.9 14.01±2.4 6.74±2.09 9.6p <0.05 NS NS 0.000 NS 0.1>p>0.05 0.02A lower score in the physical perfformance and a tendency to a lesser left hip abduction inwomen with 25OHD £20ng/ml was observed. Preliminary data show that the levels ofinsufficient vitamin D could predict physical performance in osteopenic/osteoporoticwomen >65.