Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism

ZANCHETTA, MARÍA BELÉN; ROBBIANI, DAMIÁN; OLIVERI, BEATRIZ; GIACOIA, EVANGELINA; FRIGERI, ADRIANA; KALLSBRUM, SILVIA; SALERNI, HELENA; LUCAS, SABRINA; DIAZ, ADRIANA; PEREZ, BETIANA; PIERONI, LUISINA; ARCE LANGE, MARÍA AUXILIADORA; TORMO, SILVINA; KITAIGRODSKY, ARIELA; GALICH, ANA MARÍA

Journal of the Endocrine Society

OXFORD ACADEMIC

Año: 2021 vol. 5

Context: Hypoparathyroidism is a rare disease and, as such, its natural history, long-termcomplications, and correct clinical management remain unclear.Objective: To describe the natural history and clinical characteristics of the disease.Design and Setting: To present a retrospective observational analysis from 7 specializedcenters in Buenos Aires, Argentina.Patients: Chronic hypoparathyroid patients followed-up between 1985 and December 2018.Main Outcome Measures: Data on demographics, etiology, clinical complications, biochemicalparameters, dual-energy x-ray absorptiometry (DXA) values, and treatmentdoses were collected.Results: A total of 322 subjects with chronic hypoparathyroidism were included; 85.7%were female, the mean age was 55.2 ± 16.8 years, and the mean age at diagnosis was43.8 ± 16.8 years. Prevalence of surgical hypoparathyroidism was 90.7%, with the mostcommon causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemiarequiring hospitalization was present in 25.7% of the whole group and in 4.3%of patients who had a history of seizures. Overall, 40.9% of our patients had reported atleast 1 neuromuscular symptom. Renal insufficiency was present in 22.4% of our patientsand was significantly associated with age (P < 0.0001). Hyperphosphatemia was presentin 42% of patients. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications,seizures, and cataracts was significantly higher in nonsurgical patients.