INVESTIGADORES
OLIVERI Maria Beatriz
artículos
Título:
Effect of doxercalciferol (1alfa hydroxyvitamin D2) on PTH, bone turnover and bone mineral density in a hemodialysis patient with persistent secondary hypreparathyroidism post-parathyroidectomy.
Autor/es:
PARISI MS; OLIVERI BEATRIZ; SOMOZA J; MAUTALEN C
Revista:
CLINICAL NEPHROLOGY
Editorial:
DUSTRI-VERLAG DR KARL FEISTLE
Referencias:
Año: 2003 vol. 59 p. 471 - 474
ISSN:
0301-0430
Resumen:
Abstract. The eftleacy and safety of the
vitamin D analog, doxerealciferol (lo.hy-
droxyvitamin D2, lo·.D2) in the treatment of
secondary liyperpaiathyroidisin in hemo-
dialysis patients has been previously re-
ported. We report thse eftect of lo-week
lrrD2 treatment on rnineral metabolism and
bone mineral density (BMD) inahemodialysis
patient with persistent secondary liyperpara-
tliyroidi.sm post parathyroiclectoiny, resistant
to previous ealeitriol treatment. Levels of
iPTll, bone-specilie alkaline phosphatase
and serum type `I collagen C telopeptide were
above normal at baseline and were substan-
tially decreased with lo.]32 treatment (-92%,
-63% and -53%, respectively). BMD in-
creased in all areas: total skeleton (+6.5%),
lumbar spine (+6.9%) and total femur
(+4.3%). The patient showed no hypereal-
eemia, and phosphorus levels remained be-
tween 3.3 and 6.2 mgfdl.