INVESTIGADORES
SANTA COLOMA Tomas Antonio
artículos
Título:
Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
Autor/es:
THOMAS MG; SANTA COLOMA TA,; CORREALE J; BOCCACCIO GL
Revista:
NEUROCHEMICAL RESEARCH
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Lugar: New York; Año: 2002 vol. 27 p. 1305 - 1312
ISSN:
0364-3190
Resumen:
Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligodendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
