In-vitro and bioinformatic analyses demonstrate the involvement of FOXM1 in hormone receptor signaling in prostate cancer.

BRANDANI JAVIER; BIZZOTO, JUAN; ABBATE MERCEDES; LEONARDI DAIANA; GUERON GERALDINE; ELBA VAZQUEZ; COTIGNOLA JAVIER

Congreso; Advances in prostate cancer research; 2020

Dysregulation of the androgen receptor (AR) and glucocorticoid receptor (GR) expressionis responsible, at least in part, for the development and progression of prostate cancer(PCa). GR might also have oncogenic or tumor suppressor activities depending on thepresence/absence of AR and other regulatory cofactors such as the Forkhead Box (FOX).The FOX family is comprised of over 40 proteins involved in cell proliferation, migration,invasion and differentiation.Our hypothesis was that FOXs expression alters AR/GR signaling and, in turn, PCaphenotype. Therefore, we aimed to study FOXs expression and their involvement inAR/GR signaling and PCa phenotype.We first studied the gene expression of all FOX family members using the GSE6919dataset which is comprised of: 17 normal prostates, 60 non-tumoral adjacent tissues, 144primary PCa, and 22 metastatic PCa. We selected the FOX factors that were differentiallyexpressed among all pairwise comparisons (t-test/FDR p