INVESTIGADORES
VAZQUEZ Elba Susana
artículos
Título:
Prostate cancer cell?stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases
Autor/es:
WAN X; CORN P; YANG J; PALANISAMY N; STARBUCK M; EFSTATHIOU E; LI-NING TAPIA E; ZURITA A; APARICIO A; RAVOORI M; VAZQUEZ E; ROBISON D; WU Y; CAO X; IYER M; MCKEEHAN W; KUNDRA V; WANG F; TRONCOSO P; CHINNAIYAN A; LOGOTHETIS C; NAVONE N
Revista:
Science translational Medicine
Editorial:
American Association for the Advancement of Science
Referencias:
Lugar: Washington; Año: 2014 vol. 6
ISSN:
1946-6234
Resumen:
Bone is the most common site of prostate cancer (PCa) progression to a therapy-resistant, lethal phenotype. We found that blockade of fibroblast growth factor receptors (FGFRs) with the receptor tyrosine kinase inhibitor dovitinib has clinical activity in a subset of men with castration-resistant PCa and bone metastases. Our in- tegrated analyses suggest that FGF signaling mediates a positive feedback loop between PCa cells and bone cells and that blockade of FGFR1 in osteoblasts partially mediates the antitumor activity of dovitinib by improving bone quality and by blocking PCa cell?bone cell interaction. These findings account for clinical ob- servations such as reductions in lesion size and intensity on bone scans, lymph node size, and tumor-specific symptoms without proportional declines in serum prostate-specific antigen concentration. Our findings sug- gest that targeting FGFR has therapeutic activity in advanced PCa and provide direction for the development of therapies with FGFR inhibitors.