Efecto de una mezcla de galactooligosacáridos (GOS)/ fructooligosacáridos (FOS) sobre la absorción intestinal y retención ósea de calcio, fosforo y magnesio: modelo experimental en ratas durante el crecimiento norma.

BRYK G, . ; ZENI CORONEL M, ; MEDINA D, ; PELLEGIRNI G, ; PORTELA ML DE, ; ZENI SN.

Actualizaciones en Osteologia

Asoc. Arg. de Osteoporosis y Metabolismo Mineral

Lugar: Rosario; Año: 2013 vol. 9 p. 243 - 253

1669-8975

Calcium requirements are generally not covered regardless of age and socioeconomic status. Increase Ca intake would be adequate to prevent deficiency; however, if it is not possible, to increase intestinal absorption would be an useful tool to obtain an extra-supply of mineral. Colonic flora fermentation of galactooligosaccharides (GOS) and fructooligosaccharides (FOS) enhances active and passive Ca absorption. Objective:  to evaluate GOS/FOS® effect on Ca, Mg and P absorption and retention in an experimental growing rat model. Methods: At weaning, Wistar male rats (n = 8) received AIN93-G (A), Vital, Nutrilon or Nutrilon Lactose Free (N, V and NSL respectively) formula milks until 40 days of life. NSL and N supplies 5.3% of GOS / FOS ® while A and V does not. Food consumption, Ca, Mg and P absorption, and lactobacilli development in fresh feces was evaluated weekly; caecum pH, femur mineral content and biomechanical, total skeleton mineral and subareas of bone mineral content and density (BMC, BMD) (Lunar DXA) were measured after sacrifice Results: No significant differences in caloric terms of food consumption were found among groups. N and NSL increased lactobacilli development (p