Body mass index effect on total and undercarboxilated osteocalcin in normoglucemic adult men.

LUGONES C,; BONNANO M; BRITO G; WATSON D,; REY SARAVIA MARIANA; ZAGO L; GONZALEZ INFANTINO C,; ZENI SN

budapest

Congreso; 46th European Calcified Tissue Society Congress (ECTS-2019).; 2019

Obesity and osteoporosis, two of the main common chronic diseases are interconnected. Regarding, both pathologies come from the deregulation of a common mesenchymal precursor. Moreover, bone through osteocalcin (OCN) and fat tissue through leptin appear to contribute to glucose homeostasis. The objective of this study was to evaluate the effect of BMI on serum levels of total OCN and undercarboxilated OCN (ucOCN), in non-diabetic overweight and obese adult men who were divided according to quartiles of BMI (range 29.0 to 47 kg/m2). We determined ucOCN, OCN, leptin and insulin, in 54 adult non-diabetic men, having normal levels of glucose (80 to 110 mg/dL) and hemoglobin A1c (HbA1c