Body composition and bone markers in obese (â) growing rats: Influence of the dietary calcium content

WEISSTAUB A; HERNáNDEZ E, ; GONZALES-CHAVES MMS, ; PELLEGRINI GG, ; MAROTTE C, ; OLGUIN M, ; LABOURDETTE V, ; PORTELA ML, ; ZENI SN

Buenos Aires

Congreso; XVI Reunión Anual de la AAOMM.; 2009

AAOMM

Osteoporosis and obesity are interrelated. We compare the effect of feeding different dietary Ca levels on body weight (BW) and composition and its relation to bone markers levels, in genetically modified obese (âO) rats during growth. Rats were mated and fed diets varying Ca content (g/100 g): high, 0.9 (GâH); normal, 0.5 (GâN); low, 0.2 (GâL). A Wistar group was run simultaneously (GCW) (fed according to AIN93). At weaning, male pups continued feeding the same diet till 50 days of age. Food consumption and BW were recorded. At the end of the experience, body composition, BAP, BGP, and CTX were determined. Results (mean±SD): Food intake was similar in all groups. BW was lower in GâH vs. N and H groups (162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g) increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04± 0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90± 0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âO) rats during growth. Rats were mated and fed diets varying Ca content (g/100 g): high, 0.9 (GâH); normal, 0.5 (GâN); low, 0.2 (GâL). A Wistar group was run simultaneously (GCW) (fed according to AIN93). At weaning, male pups continued feeding the same diet till 50 days of age. Food consumption and BW were recorded. At the end of the experience, body composition, BAP, BGP, and CTX were determined. Results (mean±SD): Food intake was similar in all groups. BW was lower in GâH vs. N and H groups (162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g) increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04± 0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90± 0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âH); normal, 0.5 (GâN); low, 0.2 (GâL). A Wistar group was run simultaneously (GCW) (fed according to AIN93). At weaning, male pups continued feeding the same diet till 50 days of age. Food consumption and BW were recorded. At the end of the experience, body composition, BAP, BGP, and CTX were determined. Results (mean±SD): Food intake was similar in all groups. BW was lower in GâH vs. N and H groups (162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g) increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04± 0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90± 0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âN); low, 0.2 (GâL). A Wistar group was run simultaneously (GCW) (fed according to AIN93). At weaning, male pups continued feeding the same diet till 50 days of age. Food consumption and BW were recorded. At the end of the experience, body composition, BAP, BGP, and CTX were determined. Results (mean±SD): Food intake was similar in all groups. BW was lower in GâH vs. N and H groups (162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g) increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04± 0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90± 0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âH vs. N and H groups (162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g) increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04± 0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90± 0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.â as dietary Ca content increases (1.26±0.42, 2.04± 0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90± 0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âL and GâN (14.7±1.3 and 13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âH (12.6±2.2; p<0.05). BAP (IU/L) did not show differences among Gâ groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.â groups (186±27, 193±39 and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.â (447±45, 375±46, and 279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml) did not show differences between GCW (88±16) and GâH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âH (87±4) but they were higher than GâN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âN and GâL (69±12 and 70±3, respectively; p<0.01). Conclusions: In âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.âO rats, the increase in dietary Ca content decreased BW changes and body lipids content and increased total BMC. Bone markers suggest an imbalance in bone metabolism related to the adipose tissue. UBACYT B 091.