INVESTIGADORES
ZENI Susana Noemi
congresos y reuniones científicas
Título:
Different osteoblastic growth period (formation, maturation and mineralization) evaluated by different biochemical bone markers
Autor/es:
CASCO C; LEONHARDT L; MASTAGLIA S; SEIJO M; DEFERRARI J; SOMOZA, J; BAGUR ALICIA; OLIVERI BEATRIZ; ZENI SUSANA N
Lugar:
Buenos Aires
Reunión:
Congreso; XXII Reunión Anual de Asociación Argentina de Osteologia y Metabolismo Mineral; 2005
Institución organizadora:
Asociación Argentina de Osteologia y Metabolismo Mineral
Resumen:
The osteoblast differentiation involves three periods: bone matrix formation by procollagen synthesis; its maturation by deposit of non collagen proteins like osteocalcin (BGP) and matrix mineralisation, where bone alkaline phosphatase (b-AP) is an important factor. Osteoblastic activity can be easily measured in serum by biochemical bone formation markers. Three bone formation markers were evaluated to determine if the different osteoblastic period can be identify in normal conditions. Fasting blood (8 a 10.30 am) was drawn from healthy adult (126: 61 men, 65 women) aged 22 to 49 to assess P1NP(ng/L) and BGP (ng/L) (Elecsys 1010, Roche Arg.) and b-AP (UI/L) after specific wheat germ lectin precipitation. Results (X ± SD) were divided by genera and decades (years): G 1: 2029, G 2: 3039 years G3: 4049. Men vs. women: b-AP did not present differences in G1: 67 ± 10 vs. 64 ± 8, but G2 (61 ± 13 vs. 72 ± 12, P < 0.02) and G3 (62 ± 11 vs. 73 ± 14, P < 0.05) did; BGP and P1NP only in G3 (8.7 vs. 24.9 ± 8.3 P < 0.05 and 42.8 ± 15.9 vs. 57.7 vs. 21.6, P < 0.05, respectively). Among men: BGP presented differences between G1 and G2 (28.8 ± 10.1 vs. 20.6 ± 6.9 P < 0.02) and P1NP between G1 vs. G2 and vs. G3 (71.5 ± 24.8 vs. 45.0 ± 16.2 and 42.8 ± 15.9, respectively, P < 0.05). Among women: BGP was significant different between G1 vs. G2 and vs. G3 (27.2 ± 10.0 vs. 20.2 ± 8.2 and 24.9 ± 8.3, respectively, P < 0.002) and P1NP was different between G1 and G3 (72.3 ± 24.9 vs. 57.7 ± 21.6, respectively, P < 0.001). Conclusions: Bone formation and mineralization period have a similar behavior but same differences might exist in bone maturation ones.
