INVESTIGADORES
ZENI Susana Noemi
congresos y reuniones científicas
Título:
Body composition and bone markers in obese (â) growing rats: Influence of the dietary calcium content
Autor/es:
WEISSTAUB A; HERNáNDEZ E, ; GONZALES-CHAVES MMS, ; PELLEGRINI GG, ; MAROTTE C, ; OLGUIN M, ; LABOURDETTE V, ; PORTELA ML, ; ZENI SN
Lugar:
Buenos Aires
Reunión:
Congreso; XVI Reunión Anual de la AAOMM.; 2009
Institución organizadora:
AAOMM
Resumen:
Osteoporosis and obesity are interrelated. We compare the effect
of feeding different dietary Ca levels on body weight (BW) and
composition and its relation to bone markers levels, in genetically
modified obese (âO) rats during growth. Rats were mated and fed
diets varying Ca content (g/100 g): high, 0.9 (GâH); normal, 0.5
(GâN); low, 0.2 (GâL). A Wistar group was run simultaneously
(GCW) (fed according to AIN93). At weaning, male pups continued
feeding the same diet till 50 days of age. Food consumption and BW
were recorded. At the end of the experience, body composition, BAP,
BGP, and CTX were determined. Results (mean±SD): Food intake
was similar in all groups. BW was lower in GâH vs. N and H groups
(162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g)
increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04±
0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90±
0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âO) rats during growth. Rats were mated and fed
diets varying Ca content (g/100 g): high, 0.9 (GâH); normal, 0.5
(GâN); low, 0.2 (GâL). A Wistar group was run simultaneously
(GCW) (fed according to AIN93). At weaning, male pups continued
feeding the same diet till 50 days of age. Food consumption and BW
were recorded. At the end of the experience, body composition, BAP,
BGP, and CTX were determined. Results (mean±SD): Food intake
was similar in all groups. BW was lower in GâH vs. N and H groups
(162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g)
increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04±
0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90±
0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âH); normal, 0.5
(GâN); low, 0.2 (GâL). A Wistar group was run simultaneously
(GCW) (fed according to AIN93). At weaning, male pups continued
feeding the same diet till 50 days of age. Food consumption and BW
were recorded. At the end of the experience, body composition, BAP,
BGP, and CTX were determined. Results (mean±SD): Food intake
was similar in all groups. BW was lower in GâH vs. N and H groups
(162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g)
increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04±
0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90±
0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âN); low, 0.2 (GâL). A Wistar group was run simultaneously
(GCW) (fed according to AIN93). At weaning, male pups continued
feeding the same diet till 50 days of age. Food consumption and BW
were recorded. At the end of the experience, body composition, BAP,
BGP, and CTX were determined. Results (mean±SD): Food intake
was similar in all groups. BW was lower in GâH vs. N and H groups
(162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g)
increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04±
0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90±
0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âH vs. N and H groups
(162±18 vs. 217±31 and 221±37; p<0.01). Ash content (g/100 g)
increased in Gâ as dietary Ca content increases (1.26±0.42, 2.04±
0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90±
0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.â as dietary Ca content increases (1.26±0.42, 2.04±
0.25, 2.51±0.17; p<0.01), without reaching GCW values (2.90±
0.40). Lipid percentage was higher in GâL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âL and GâN (14.7±1.3 and
13.6±2.7) vs. GCW (10.9±2.6) and in GâH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âH (12.6±2.2; p<0.05). BAP
(IU/L) did not show differences among Gâ groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.â groups (186±27, 193±39
and 184±30), being higher vs. GCW (67.8±10.0). BGP showed an
inverse correlation with dietary Ca level in Gâ (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.â (447±45, 375±46, and
279±73), being lower than GCW (825±106; p<0.01). CTX (mg/ml)
did not show differences between GCW (88±16) and GâH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âH (87±4)
but they were higher than GâN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âN and GâL (69±12 and 70±3,
respectively; p<0.01). Conclusions: In âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.âO rats, the increase in dietary
Ca content decreased BW changes and body lipids content and
increased total BMC. Bone markers suggest an imbalance in bone
metabolism related to the adipose tissue. UBACYT B 091.