Vitamin D insufficiency in two groups of women from Southern Argentina: Seasonal effect.

PELLEGRINI G; GONZALES-CHAVES MMS, ; FAJARDO M, ; PONCE GM, ; SOMOZA J, ; TOYOS GI, ; ZENI SN

Buenos Aires

Congreso; XXVI Reunión Anual de la AAOMM.; 2009

AAOMM

Although it is frequent in elderly people, young adults may also be at risk of having inadequate vitamin D status. On this basis, 25HOD was evaluated at the end of winter and summer in the same group of women to observe: seasonal changes in vitamin D status and its effect on PTH and bone markers levels. Healthy women from two Southern cities of Argentina: Cro. Rivadavia (45-S) and Ushuaia (54-S) (20 pre and 20 postmenopausal) were studied in March and August. In fasting blood 25HOD (ng/ml) (Diasorin), PTHmm (pg/ml), b-ALP (IU/L) and CTX (ng/L) (Crosslaps, Osteometer Bio Tech) were evaluated. Results: Mean±SD levels at the end of winter and summer  were: Premenopausal: 25HOD: 13,8±5,3; 23,9±10,4* PTH: 51,6±17,8; 52,6±37,3, b-ALP: 56±10; 61±11, CTX: 223,0±69,2; 217,8±77,1. Postmenopausal: 25HOD: 14,2±7,2; 23,1±10,6* PTH: 59,3±25,2; 54,8±36,1, b-ALP: 62±15; 73±20 , CTX: 313,1±119,4**; 335,8±137,9**. (*) P < 0.05: summer vs. winter within the same group, (**) P < 0.05: pre vs. postmenopausal in the same season. The 100% of the pre and the 95% of the postmenopausal women had inadequate levels of 25HOD at the end of winter while at the end of summer reached 65 % in premenopausal and 78% in postmenopausal women. For all women PTH levels presented a negative correlation with 25HOD levels. (r= -0.313 p>0.024). Bone markers increase in pre vs. postmenopausal in both seasons without differences between winter and summer for the same group. Conclusion: Even at the end of the summer premenopausal women had a high 25HOD insufficiency percentage. Grant from Buenos Aires University M099.