RESORBED ALVEOLAR BONE RECOVERY BY TREATMENT WITH PTH 1-34 AT LOW DOSES IN EXPERI- MENTAL PERIODONTITIS

BONANNO MS,; ZENI CORONEL EM; SEIJO M; BIDEVICH NL; AVENDAÑO ME; PRELIASCO M; DAVISON MR; ZENI SN

Congreso; REUNIÓN CONJUNTA SAIC SAI&FAIC SAFIS 2022; 2022

We compared two low doses of PTH for the recovery of alveolarbone loss by experimental periodontitis. Periodontitis was inducedin 18 female Wistar rats (221±15g); 96 hours later, rats were dividedand treated by injection into the gingival sulcus: G1: saline solution(SS), G2 and G3 with 0.2 or 0,4 μg PTH 1-34/Kg/3 times a week.A control group (C) (n=5) without ligature was injected with SS. Af-ter 21 days, serum was extracted to determine CrossLapp (CTX),osteocalcin (OCN) and PTH by ELISA. Animals were euthanizedand hemimandibles (HM) and tibias (T) were extracted for histomor-phometry (percent bone volume: BV/TB% and periodontal spaceheight: PSA). Results (C, G1, G2 y G3 respectively. Mean±SD, dif-ferent letters indicate p