INVESTIGADORES
ZENI Susana Noemi
artículos
Título:
Telopéptido carboxilo terminal del colágeno tipo I (beta-CTX) sérico y compromiso óseo en la insuficiencia renal crónica.
Autor/es:
OLIVERI BEATRZ; WITTICH ANA C; NADAL JUAN C; ZENI SUSANA N
Revista:
MEDICINA (BUENOS AIRES)
Editorial:
MEDICINA (BUENOS AIRES)
Referencias:
Lugar: Buenos Aires; Año: 2005 vol. 65 p. 321 - 328
ISSN:
0025-7680
Resumen:
An increase in parathyroid hormone (PTH) levels in chronic renal failure (CRF) induces bone abnormalities known as renal osteodystrophy (ROD). The aim of the present study was to evaluate alternative biochemical methods to bone biopsy, to evaluate changes in bone remodeling in renal patients. Intact PTH (iPTH) and bone markers were measured in 43 predialysis (PD), 49 hemodialysis patients (HD) and 185 controls. betaCTXs, bone alkaline phosphatase (bAL), iPTH were higher and creatinine clearance (Ccr) was lower in PD and HD compared with controls (p < 0.0001). In both renal groups, a positive correlation was found between iPTH and both betaCTXs and bAL (p < 0.0001) and between betaCTXs and bAL (p < 0.002). PD patients with Ccr < 40 ml/min had higher iPTH, bAL and betaCTXs (p
