Growth hormone (GH) deficiency status combined with GH receptor polymorphism affects response to GH in children.

VALSESIA A; CHATELAIN P; A STEVENS; PETERKOVA V; BELGOROSKY A; MAGHNIE M; ANTONIAZZI F; KOLEDOVA E; WOJCIK J; FARMER P; DESTENAVES B; CLAYTON PE

EUROPEAN JOURNAL OF ENDOCRINOLOGY

BIOSCIENTIFICA LTD

Lugar: Bristol; Año: 2015

0804-4643

Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n=45) and >4 to