Agarofuran Sesquiterpenes from Schaefferia argentinensis as Potential Antiproliferative Agents

GARCÍA, M.; MOTTRICH, R.; CAPUTTO, B.; SANCHEZ, M.; PALERMO, J.; ESTEVEZ BRAUN, A.; GUTIERREZ RAVELO, A.; NICOTRA, V.

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2013 vol. 91 p. 260 - 267

0031-9422

Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. The structures of these compounds were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines. The activity observed for the tested compounds was marginal.