INVESTIGADORES
THOMAS Andres Hector
artículos
Título:
Study of the photolysis of folic acid and 6-formylpterin in acid aqueous solutions
Autor/es:
ANDRÉS H. THOMAS; GUSTAVO SUÁREZ; FRANCO M. CABRERIZO; RAÚL MARTINO; ALBERTO L. CAPPARELLI
Revista:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Editorial:
Elsevier
Referencias:
Año: 2000 vol. 135 p. 147 - 154
ISSN:
1010-6030
Resumen:
Folic acid and 6-formylpterin solutions of pH in the range 4.56.0 were photolysed at 350 nm at room temperature. The photochemical
reactions were followed by UVVIS spectrophotometry, thin layer chromatography (TLC) and high performance liquid chromatography
(HPLC). In the presence of oxygen, folic acid is photochemically cleavaged yielding 6-formylpterin and p-aminobenzoylglutamic acid.
As the photolysis proceeds, 6-carboxypterin arises from 6-formylpterin, as observed when solutions only containing the latter compound
are irradiated in the presence of oxygen. In the absence of oxygen, folic acid is not light-sensitive. However, when oxygen free solutions
of 6-formylpterin are irradiated, a red intermediate is observed, which is thermally oxidised producing 6-carboxypterin on admission of
oxygen. The quantum yields of substrates disappearance and of photoproducts formation are reported. © 2000 Elsevier Science S.A. All
rights reserved.p-aminobenzoylglutamic acid.
As the photolysis proceeds, 6-carboxypterin arises from 6-formylpterin, as observed when solutions only containing the latter compound
are irradiated in the presence of oxygen. In the absence of oxygen, folic acid is not light-sensitive. However, when oxygen free solutions
of 6-formylpterin are irradiated, a red intermediate is observed, which is thermally oxidised producing 6-carboxypterin on admission of
oxygen. The quantum yields of substrates disappearance and of photoproducts formation are reported. © 2000 Elsevier Science S.A. All
rights reserved.