Long lasting effects of neonatal bisfenol Aexposure on the implantation process

VARAYOUD J; RAMOS JG; MUÑOZ DE TORO M; LUQUE EH

Vitamins and Hormones

Elsevier

Año: 2014; p. 1 - 25

Successful implantation is the result of complex molecular interactions between thehormonally primed uterus and a mature blastocyst. This very carefully synchronizedinterplay of hormonal signals and feedback loops is potentially vulnerable to chemicalssuch as endocrine disruptors that may disrupt endocrine signaling. Bisphenol A (BPA)is one of the highest-volume chemicals produced worldwide. This chapter describesthe effects of brief postnatal exposure to BPA on female reproductive performanceand specifically on the uterine adaptations during the preimplantation period.We propose that an early alteration in Hoxa10 gene expression affects the functionaldifferentiation of the preimplantation uterus as part of an altered endocrine signaltransduction pathway. These molecular alterations could explain, at least in part, the adverse effects of BPA on uterine implantation. Exposure to endocrine disruptors,such as BPA, could contribute to the impaired female fertility noted over the pastdecades.