Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

GIOLITO, MARÍA V; CAMACHO, CRISTIAN M; MARTINEZ-AMEZAGA, MAITENA; TRAFICANTE, CARLA I; GIORDANO, ROCÍO A; CORNIER, PATRICIA G; MATA, ERNESTO G; DELPICCOLO, CARINA ML; BOGGIÁN, DORA B; GIÚDICE, ANTONELA DEL; MAINETTI, LEANDRO E; SCHAROVSKY, OLGA G; ROZADOS, VIVIANA R; RICO, MARÍA J

Future Science OA

Future Science

Lugar: Londres; Año: 2020 vol. 6

In spite of the important progress achieved in cancer therapeutics, the percentage of people dying because of cancer is still high. Hence, we need to develop new, effective and nontoxic anticancer agents. We synthetized novel compounds and tested their antitumor effect and toxicity, in order to choose those that are effective and do not affect normal cells and therefore, are suitable for human cancer therapies. We selected three out of 35 compounds that show high antitumor action and low toxicity. Also, we studied the mechanisms by which that effect was achieved. Our next goal is to develop experiments with animals in order to have preclinical data that, hopefully, will lead to the clinical use of one or more of the selected compounds