INVESTIGADORES
MATA Ernesto Gabino
artículos
Título:
Synthesis and β-lactamase inhibitory evaluation of novel 6α-halo-2β-chloromethyl-2α-methylpenam-3α-carboxy lic acids and their sulfones and 6α-halo-2β-mercaptobenzothiazolylmethyl-2α-methylpenam- 3α-carboxylic acids
Autor/es:
DANELON, GERARDO O.; MATA, ERNESTO G.; MASCARETTI, ORESTE A.; GIRARDINI, JAVIER; MARRO, MARTIN; ROVERI, OSCAR A.
Revista:
BIORGANIC AND MEDICINAL CHEMISTRY LETTERS
Editorial:
elsevier
Referencias:
Año: 1995 vol. 5 p. 2037 - 2040
ISSN:
0960-894X
Resumen:
The synthesis and the inhibitory activity against β-lactamase I from Bacillus cereus is described for a new series of 6α-bromo, chloro or fluoro-2β-chloromethyl-2α-methylpenam-3α-carboxylic acids (5a-c) and their corresponding sulfones 6a-c and 6α-bromo, chloro or fluoro-2β-mercaptobenzothiazolylmethyl-2α-methylpenam-3 α-carboxylic acids (8a-c). Among the novel compounds, the highest activity was expressed by 6α-chloro-2β-chloromethyl-2α-methylpenam-3α-carbo xylic acid 1,1-dioxide (6b). © 1995.
