Chemoenzymatic synthesis of novel N-(2-hydroxyehtyl)-â-peptoid oligomer derivatives and aplication to porous polycaprolactone films

L. N. MONSALVE, ; G. PETROSELLI, ; R ERRA-BALLSELLS, ; A VáZQUEZ ; A BALDESSARI

Polymer International

Elsevier

Lugar: Amsterdam; Año: 2014 vol. 63 p. 1523 - 1530

1097-0126

Poly[N-(2-hydroxyethyl)-â-propylamide] oligomer is synthesized using a simple enzymatic procedure involving Candida antarctica lipase B. This novel compound is obtained by a green and chemoselective method from economic reactants in good yield. The â-peptoid oligomer is characterized by spectroscopic methods showing low molecular weight and low dispersity. Two derivatives of the â-peptoid oligomer are prepared by acetylation and by grafting polycaprolactone by ring opening polymerization from the pendant hydroxyl groups. These products are blendedwith polycaprolactone to make films by solvent casting. The inclusion of the acyl derivatives of the â-peptoid to polycaprolactone affects the morphology of the film yielding microstructured and nanostructured patterns.