IFLP 13074
INSTITUTO DE FISICA LA PLATA
Unidad Ejecutora - UE
artículos
Título:
Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical and biological characterization
Autor/es:
G. V. LÓPEZ; F. BLANCO; P. HERNÁNDEZ; A. FERREIRA; O. E. PIRO; C. BATTHYÁNY; M. GONZÁLEZ; H. RUBBO; H. CERECETTO
Revista:
Bioorganic and Medicinal Chemistry
Editorial:
Elsevier
Referencias:
Año: 2007 vol. 15 p. 6262 - 6272
Resumen:
Synthesis, physicochemical, and biological characterization of a series of a-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilichydrophilic balance of all products was also evaluated.A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.
