Effects of scopolamine and propranolol on a treatment that facilitates recovery from frustration.

NADIA JUSTEL; RICARDO PAUTASSI; MARIANA PSYRDELLIS

Buenos Aires

Congreso; 2do. Congreso de la Federación de Sociedades de Neurociencias de Latinoamérica y el Caribe (FALAN) XXXI Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2016

FALAN

The consummatory successive negative contrast (cSNC) paradigm is an animal model for the study of frustration in which acceptance of 4% sucrose solution is assessed in animals that had been exposed to 32% sucrose solution. These downshifted animals usually exhibit significantly less sucrose acceptance than animals that always received the 4% sucrose solution. On the other hand, exposing rats to a novel situation, as the exploration of an open field (OF) is a complex situation that involves several behavioral processes, including stress induction and novelty detection. OF exposure can modulated the memory of frustration following different patterns. Prior to the first downshift trial (T1, first 4% trial) generates memory impairment on frustration. The opposite pattern was observed when the OF was applied prior to the second trial (T2) as it generates an accentuation of frustration. The aim of this work was to assess the effect of OF exposition after the acquisition of the downshifted memory (OF applied after T1) with the goal to target the consolidation of this mnemonic trace. Also, we investigated the involvement of the cholinergic and adrenergic systems in the phenomenon by the administration of propranolol (noradrenergic antagonist) and scopolamine (cholinergic antagonist). The main results indicated that OF facilitates recovery from the reward loss and that both cholinergic and adrenergic systems play a role in the OF effect. These results provide new information on functional and pharmacological effect of a non-invasive way of memory modulation.