Asistente 60th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease

SOOKOIAN, SILVIA

Texas

Congreso; Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease.; 2006

American Heart Association

The renin-angiotensin-aldosterone system is an important regulator of blood pressure. Variants in their component-encoding genes have been associated with essential hypertension and hypertrophic cardiomyopathy. Among them the CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been extensively studied but its role in hypertension and related phenotypes remains controversial. Then, we performed a systematically review of the literature by means of a meta-analysis to evaluate the influence of the CYP11B2 C-344T polymorphism on the occurrence of arterial hypertension and related phenotypes. From 485 reports, we included 42 observational studies, case control and cohort at baseline. A fixed-effect model was used to pool data from individual studies. From 4741 essential hypertensive and 5444 control subjects, we found a significant association between hypertension and the C-344T variant showing a protective effect of the C allele (OR: 0.819, 95 % CI: 0.743 to 0.902, p< 0.0001,n: 10185). Besides, homozygous CC subjects had lower plasma renin activity (D: -0.109, 95 % CI: -0.213 to -0.006, p<0.039, n: 1876) and posterior wall thickness (D: -0.151, 95 % CI: -0.265 to -0.037, p< 0.01, n: 1235). No significant association was found for systolic arterial blood pressure (D: -0.020, 95 % CI: -0.072 to 0.032, p=0.44, n: 7432), diastolic arterial blood pressure (D: -0.023, 95 % CI: -0.075 to 0.028, p=0.37, n: 7432) and plasma aldosterone (D: 0.016, 95 % CI: -0.085 to 0.117, p=0.755, n: 1678). Although left ventricular mass (LVM) was not different in total combined studies (p= 0.078, n: 1746), it was lower in Caucasians homozygous CC (D: -0.106, 95 % CI: -0.207 to –0.006, p< 0.04, n: 1591). In conclusion, homozygous individuals for the –344C CYP11B2 variant are at 20% lower risk of developing hypertension and may have decreased LVM.