CONICET | Buscador de Institutos y Recursos Humanos

The synthesis of 3-N-acyl-1,3,4-oxadiazolines is a well-known reaction and there is a lot of information on this field, however in recent years the number of publications has increased due to the great potential of this heterocyclic ring as chemotherapeutic agent.1,2 Nevertheless, some aspects of heterocyclization reaction are not well known. Looking for new potential biological agents, we studied the differences between heterocyclization of acylhydrazone and semicarbazone obtained from protected carbohydrate derivatives. Also, a hypothesis for their different behavior is proposed.