CIHIDECAR 12529
CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Unidad Ejecutora - UE
artículos
Título:
Synthesis of Galacturonate containing dsaccharides and protein conjugates.
Autor/es:
M. POURCELOT,; M. BARBIER; M. LANDONI,; A. S. COUTO; E. GRAND; J. KOVENSKY
Revista:
CURRENT ORGANIC CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Oak Park; Año: 2011 vol. 15 p. 3523 - 3534
ISSN:
1385-2728
Resumen:
The synthesis of galacturonate disaccharides has been performed from suitable protected monosaccharides. The use oforthogonal protecting groups allowed us to obtain both methyl galacturonates and galacturonic acid precursors as glycosylation donors oracceptors from a unique monosaccharide derivative. The protecting groups used allowed selective introduction of a fatty acid chain to thenon-reducing end of a disaccharide. Furthermore, we explored the preparation of galacturonate conjugated to a carrier protein, anddetermined the number of sugar residues coupled to the protein by MALDI-MS.
