Comparative Analysis of Hydrogen Peroxide and Peroxynitrite Reactivity with Thiols

ARI ZEIDA; RAFAEL RADI; SEBASTIÁN CARBALLAL; MADIA TRUJILLO

Hydrogen Peroxide Metabolism in Health and Disease

CRC Press Taylor&Francis

Año: 2017; p. 49 - 79

CONTENTSIntroduction.....49Hydrogen Peroxide and Peroxynitrite as Biologically Relevant Peroxides......49Physicochemical Characteristics of H2O2 and Peroxynitrite.......50Biologically Relevant Thiol-Containing Compounds........51Hydrogen Peroxide- and Peroxynitrite-Mediated Thiol Oxidations.......53Direct Reactions of H2O2 and Peroxynitrite with Thiols .........53Fast Reacting Thiols.........56Thiol Oxidation by Peroxides and Redox Signaling........59Reactions with Carbon Dioxide..........60Indirect Reactions of H2O2 and Peroxynitrite with Thiols.......62Diffusion Capabilities across Biological Membranes........63Preferential Targets for H2O2 and Peroxynitrite in Different Cell Compartments64Conclusions......65Acknowledgments......66References...........66