Feline squamous cell carcinoma of the nose: Fine vs thick needles, experience with 66 patients

TELLADO MATIAS; MAGLIETTI, FELIPE; MICHINSKI, SEBASTIAN; MARSHALL, GUILLERMO

Toulouse

Congreso; 3erd World Congress on Electroporation; 2019

ISEBTT

Electrochemotherapy proved to be a very effective treatment modality for squamous cell carcinoma in feline patients. Feline patients are very sensitiveto any treatment procedure involving the nasal plane, as any discomfort impedes the patient to feed or drink water properly. This complications can besevere, and even life threatening, and can be induced by the traumatic injury of the needles of the electrodes. Four types of 4 needles electrodes were testedin this work: 1. 20G at 8mm, 2. 27G at 8 mm, 3. 20G at 4 mm and 4. 27G at 4 mm. Our results show: Group 1, achieve very good local response, but withserious side effects. Group 2, did not show significant side effects after the treatment, but responses were poorer when compared with other groups. Group3, showed very good local response, as group 1, but also with serious side effects. Group 4, showed best results, with very good local control of the disease, and practically free of side effects. The electric current circulating in group 1 and 3 were similar, as in group 2 and 4, so we consider that it is not playing a significant role in the etiology of the side effects. Poor local responses in group 2 were due to and insufficient electric field, demonstrated by computer simulations. In conclusion, thin needles at 4 mm rendered the best local response, and loger survival times with minimum side effects for feline patients with SCC in the nasal plane.