Electroporation energy in electroporation-based modeling.

G. MARSHALL; GARABALINO M. A.; M. TELLADO; F. MINOTTI; A. MARQUEZ; E. LUJAN; MARINO, M.; P TURJANSKI; N. OLAIZ

Norfolk (VA)

Congreso; 2nd. World Congress on Electroporation, Norfolk, USA, September 2017; 2017

International Society for Electroporation-Based Technologies and Treatments (ISEBTT)

We introduce the concept of electroporation energy and its use in the solution of the nonlinear Laplace equation in which the tissue electric conductivity is made dependent of the electric field, temperature, and permeabilization. The permeabilization function links the tissue and membrane multi-scale level through the electroporation energy (energy absorbed by the membrane to change its state). The total electric energy pumped into the system is mainly converted into electroporation, thermal and mechanical energies.Conclusions: The model presented is able to predict the space-time evolution of the electroporation front, electric current, pH fronts and temperature variations over a broad range of applied electric energies, with an excellent agreement with experiments. These results suggest that the model based on the concept of electroporation energy is appropriate for predicting EP based protocols. The non-thermal property of EP based protocols lies in the fact that a large portion of the total energy pumped into the system goes into the electroporation energy.