UMYMFOR 05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Synthesis of 4-azasteroids by an intramolecular Ugi reaction
Autor/es:
FERNANDO ALONSO; SOFÍA L. ACEBEDO; ANDREA C. BRUTTOMESSO; JAVIER A. RAMIREZ
Revista:
STEROIDS
Editorial:
Elsevier
Referencias:
Año: 2008 vol. 73 p. 1270 - 1276
ISSN:
0039-128X
Resumen:
In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely subtituted both at N-4 and C-5.
Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reaction. In sight of our results we concluded that this methodology can be applied to obtain 4-azasteroids targeted to find new biologically active compounds.
